US heart disease deaths: 694,708 in 2025, +5.4% vs 2019
Heart disease killed 694,708 people in the US in 2025 (provisional), 5.4% more than in 2019. Deaths jumped by about 38,000 in 2020, peaked at 702,880 in 2022 and have not returned to pre-pandemic levels.
Source: NCHS, Mortality in the United States: Provisional Data, 2025 (VSRR No. 44), data as of 2014–2025 (2025 provisional)